Gene name:
Slc12a5 (Kcc2;Kiaa1176) ;
Protein name:
Solute carrier family 12 member 5 ;
Alternative:
K-Cl cotransporter 2 (mKCC2) ;Electroneutral potassium-chloride cotransporter 2 ;Neuronal K-Cl cotransporter ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity). Interacts with AP2A1.
Function:
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
Subcellular Location:
Cell projection
dendrite
Cell membrane
Multi-pass membrane protein
Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses.
Protein Attributes:
50:
MSRRFTVTSL | PPAASAASAD | PESRRHSVAD | PRRLPREDVK | GDGNPKESSP |
100:
FINSTDTEKG | REYDGRNMAL | FEEEMDTSPM | VSSLLSGLAN | YTNLPQGSRE |
150:
HEEAENNEGG | KKKPVQAPRM | GTFMGVYLPC | LQNIFGVILF | LRLTWVVGIA |
200:
GIMESFCMVF | ICCSCTMLTA | ISMSAIATNG | VVPAGGSYYM | ISRSLGPEFG |
250:
GAVGLCFYLG | TTFAGAMYIL | GTIEILLAYL | FPAMAIFKAE | DASGEAAAML |
300:
NNMRVYGTCV | LTCMATVVFV | GVKYVNKFAL | VFLGCVILSI | LAIYAGVIKS |
350:
AFDPPNFPIC | LLGNRTLSRH | GFDVCAKLAW | EGNETVTTRL | WGLFCSSRLL |
400:
NATCDEYFTR | NNVTEIQGIP | GAASGLIKEN | LWSSYLTKGV | IVERRGMPSV |
450:
GLADGTPVDM | DHPYVFSDMT | SYFTLLVGIY | FPSVTGIMAG | SNRSGDLRDA |
500:
QKSIPTGTIL | AIATTSAVYI | SSVVLFGACI | EGVVLRDKFG | EAVNGNLVVG |
550:
TLAWPSPWVI | VIGSFFSTCG | AGLQSLTGAP | RLLQAISRDG | IVPFLQVFGH |
600:
GKANGEPTWA | LLLTACICEI | GILIASLDEV | APILSMFFLM | CYMFVNLACA |
650:
VQTLLRTPNW | RPRFRYYHWT | LSFLGMSLCL | ALMFICSWYY | ALVAMLIAGL |
700:
IYKYIEYRGA | EKEWGDGIRG | LSLSAARYAL | LRLEEGPPHT | KNWRPQLLVL |
750:
VRVDQDQNVV | HPQLLSLTSQ | LKAGKGLTIV | GSVLEGTFLD | NHPQAQRAEE |
800:
SIRRLMEAEK | VKGFCQVVIS | SNLRDGVSHL | IQSGGLGGLQ | HNTVLVGWPR |
850:
NWRQKEDHQT | WRNFIELVRE | TTAGHLALLV | TKNVSMFPGN | PERFSEGSID |
900:
VWWIVHDGGM | LMLLPFLLRH | HKVWRKCKMR | IFTVAQMDDN | SIQMKKDLTT |
950:
FLYHLRITAE | VEVVEMHESD | ISAYTYEKTL | VMEQRSQILK | QMHLTKNERE |
1000:
REIQSITDES | RGSIRRKNPA | NPRLRLNVPE | ETACDNEEKP | EEEVQLIHDQ |
1050:
SAPSCPSSSP | SPGEEPEGER | ETDPEVHLTW | TKDKSVAEKN | KGPSPVSSEG |
1100:
IKDFFSMKPE | WENLNQSNVR | RMHTAVRLNE | VIVNKSRDAK | LVLLNMPGPP |
1138:
RNRNGDENYM | EFLEVLTEQL | DRVMLVRGGG | REVITIYS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Mouse Solute carrier family 12 member 5
ELISA Kit for Mouse Solute carrier family 12 member 5
ELISA Kit for Mouse Solute carrier family 12 member 5
CLIA Kit for Mouse Solute carrier family 12 member 5
CLIA Kit for Mouse Solute carrier family 12 member 5
CLIA Kit for Mouse Solute carrier family 12 member 5
Polyclonal Antibody for Mouse Solute carrier family 12 member 5
Polyclonal Antibody for Mouse Solute carrier family 12 member 5
Polyclonal Antibody for Mouse Solute carrier family 12 member 5
Monoclonal Antibody for Mouse Solute carrier family 12 member 5
Monoclonal Antibody for Mouse Solute carrier family 12 member 5
Monoclonal Antibody for Mouse Solute carrier family 12 member 5
Protein for Mouse Solute carrier family 12 member 5
Protein for Mouse Solute carrier family 12 member 5
Protein for Mouse Solute carrier family 12 member 5
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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ILS .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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C57BL/6 .
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
C57BL/6 .
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-227 (ISOFORM 2)
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72 (ISOFORM 1);TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 532-538; 726-747; 813-819; 833-843; 952-961; 1042-1052; 1078-1085 AND 1091-1101;IDENTIFICATION BY MASS SPECTROMETRY
strain :
C57BL/6 .
tissue :
Brain .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AP2A1;MUTAGENESIS OF 680-LEU-LEU-681 AND 684-GLU-GLU-685